Li, Chun; Lu, Xunhua; Wang, Mengna; Zhang, Ling; Jiang, Jian; Yan, Shunfa; Yang, Yuanyong; Zhao, Yonglong; Zhang, Lin published the artcile< A simple and efficient asymmetric hydrogenation of heteroaromatic ketones with iridium catalyst composed of chiral diamines and achiral phosphines>, Application In Synthesis of 350-03-8, the main research area is heteroaromatic ketone iridium catalyst stereoselective enantioselective hydrogenation; heteroaryl alc preparation.
An efficient iridium catalyst composed of a simple and com. available o-methoxytriphenylphosphine and 9-Amino (9-deoxy) epi-cinchonine was applied to the asym. hydrogenation of heteroaromatic ketones. A range of simple heteroaromatic ketones were hydrogenated with good to excellent enantioselectivities and high activities. In particular, thiophene ketones and furyl ketones furnished 98.6% ee with up to 2.18 x 104(1/h) TOF. This catalytic system was of practical value.
Tetrahedron Letters published new progress about Enantioselective synthesis. 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Application In Synthesis of 350-03-8.