Ligand-Enabled Regioselectivity in the Oxidative Cross-coupling of Arenes with Toluenes and Cycloalkanes Using Ruthenium Catalysts: Tuning the Site-Selectivity from the ortho to meta Positions was written by Li, Guobao;Li, Dongze;Zhang, Jingyu;Shi, Da-Qing;Zhao, Yingsheng. And the article was included in ACS Catalysis in 2017.SDS of cas: 4373-61-9 This article mentions the following:
A Ru-catalyzed 1,1′-binaphthyl-2,2′-diyl hydrogen phosphate (BNDHP)-enabled meta C-H benzylation under the assistance of ferrocene using less sterically hindered toluene derivatives as the coupling partners has been developed. Various arenes bearing pyridyl, pyridmidyl, and pyrazolyl directing groups can be selectively coupled with toluenes at the meta positions in moderate to good yield. A mechanistic study clearly showed the site selectivity at the ortho or meta position is completely controlled by the ligand of BNDHP and the catalyst precursor. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9SDS of cas: 4373-61-9).
2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.SDS of cas: 4373-61-9