《Palladium-Catalyzed Hydroxycarbonylation of (Hetero)aryl Halides for DNA-Encoded Chemical Library Synthesis》 was written by Li, Jian-Yuan; Miklossy, Gabriella; Modukuri, Ram K.; Bohren, Kurt M.; Yu, Zhifeng; Palaniappan, Murugesan; Faver, John C.; Riehle, Kevin; Matzuk, Martin M.; Simmons, Nicholas. Safety of 4-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde And the article was included in Bioconjugate Chemistry on August 21 ,2019. The article conveys some information:
A strategy for DNA-compatible, palladium-catalyzed hydroxycarbonylation of (hetero)aryl halides on DNA-chem. conjugates has been developed. This method generally provided the corresponding carboxylic acids in moderate to very good conversions for (hetero)aryl iodides and bromides, and in poor to moderate conversions for (hetero)aryl chlorides. These conditions were further validated by application within a DNA-encoded chem. library synthesis and subsequent discovery of enriched features from the library in selection experiments against two protein targets. After reading the article, we found that the author used 4-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde(cas: 1000340-35-1Safety of 4-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde)
4-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde(cas: 1000340-35-1) belongs to pyridine derivatives. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals. Safety of 4-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde