In vitro and in vivo profile of 2-(3-di-fluoromethyl-5-phenylpyrazol-1-yl)-5-methanesulfonylpyridine, a potent, selective, and orally active canine COX-2 inhibitor was written by Li, Jin;Lynch, Michael P.;DeMello, Kristin Lundy;Sakya, Subas M.;Cheng, Hengmiao;Rafka, Robert J.;Bronk, Brian S.;Jaynes, Burton H.;Kilroy, Carolyn;Mann, Donald W.;Haven, Michelle L.;Kolosko, Nicole L.;Petras, Carol;Seibel, Scott B.;Lund, Lisa A.. And the article was included in Bioorganic & Medicinal Chemistry in 2005.Electric Literature of C6H6BrNO2S This article mentions the following:
The synthesis of a novel canine COX-2 selective inhibitor, 2-(3-difluoromethyl-5-phenylpyrazol-1-yl)-5-methanesulfonylpyridine, and its in vitro and in vivo profile are described. One pyrazole compound demonstrated excellent potency and selectivity for canine COX-2 in both in vitro and ex vivo whole blood assays. This novel COX-2 inhibitor also showed a good pharmacokinetic profile (pk) following oral (po), i.v. (iv), and s.c. dosing and demonstrated excellent in vivo efficacy in a canine synovitis model. In the experiment, the researchers used many compounds, for example, 2-Bromo-5-(methylsulfonyl)pyridine (cas: 343262-51-1Electric Literature of C6H6BrNO2S).
2-Bromo-5-(methylsulfonyl)pyridine (cas: 343262-51-1) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Electric Literature of C6H6BrNO2S