Nickel-Catalyzed Amination of Aryl 2-Pyridyl Ethers via Cleavage of the Carbon-Oxygen Bond was written by Li, Jing;Wang, Zhong-Xia. And the article was included in Organic Letters in 2017.Application In Synthesis of 2-Phenoxypyridine This article mentions the following:
Reaction of aryl 2-pyridyl ethers with amines was carried out via Ni-catalyzed C-OPy bond cleavage, giving aniline derivatives in reasonable to excellent yields. Both electron-rich and electron-poor aryl 2-pyridyl ethers and a wide range of amines can be used in the transformation. The method provides a conversion way for the 2-pyridyloxy directing group in the C-H bond functionalization reactions. In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0Application In Synthesis of 2-Phenoxypyridine).
2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Application In Synthesis of 2-Phenoxypyridine