Li, Lin published the artcileDiscovery of novel dual inhibitors of VEGFR and PI3K kinases containing 2-ureidothiazole scaffold, Product Details of C9H11N3O3, the main research area is phenylureidothiazolformamide preparation VEGFR PI3K kinase inhibitory anticancer SAR activity.
A series of compounds possessing 2-(3-phenyl)ureidothiazol-4-formamide derivatives with a 2-ureidothiazole scaffold were designed and synthesized. Some compounds demonstrated inhibition of cell proliferation against both MDA-MB-231 and HepG2 cell lines using Sorafenib as the pos. control. Compounds I showed a good to moderate inhibition on VEGFR-2 and PI3Kα which was proved by further mol. docking study. This study suggests that compound I is a potential dual inhibitor of VEGFR-2 and PI3Kα and is applicable for further investigation.
Chinese Chemical Letters published new progress about Antitumor agents. 26820-62-2 belongs to class pyridine-derivatives, name is 4-(5-Nitropyridin-2-yl)morpholine, and the molecular formula is C9H11N3O3, Product Details of C9H11N3O3.