Regio-Divergent C-H Alkynylation with Janus Directing Strategy via Ir(III) Catalysis was written by Li, Xianwei;Liang, Guangxin;Shi, Zhang-Jie. And the article was included in Chinese Journal of Chemistry in 2020.Computed Properties of C8H11N This article mentions the following:
The ‘one-to-two’ activation model was achieved by slight modification of simple and practical ketoxime and amide functionality. With judicious choice of directing groups, Csp3-H and Csp2-H bond alkynylation reaction and more significantly, dehydrogenative Csp3-H alkynylation were realized by enabling the regio-divergent late-stage modifications of pharmaceuticals. In the experiment, the researchers used many compounds, for example, 2-Isopropylpyridine (cas: 644-98-4Computed Properties of C8H11N).
2-Isopropylpyridine (cas: 644-98-4) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Computed Properties of C8H11N