Palladium catalyzed ligand-free Suzuki reaction in polyethylene glycol/H2O was written by Li, Xin-min;Chen, Zheng-jun;Hu, Qing-hong;Zhang, Yu-ting;Wang, Zheng-qin;Yuan, Ze-li. And the article was included in Huaxue Shiji in 2018.SDS of cas: 4373-61-9 This article mentions the following:
In the presence of 0.3 mol% Pd(OAc)2 and 70 mol% K2CO3, various hetero/aryl bromides could couple efficiently with aryl boronic acids in aqueous polyethylene glycol to afford biaryl products with excellent yields. This protocol shows tolerance to a diverse array of functionalized aryl bromides and boronic acids, and the highest biaryl product yield up to 98%. The absence of phosphine ligands and a large amount of base made the work-up process easier in this protocol. Moreover, this method allows the preparation of the core intermediate of valsartan in gram quantities with good yield. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9SDS of cas: 4373-61-9).
2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.SDS of cas: 4373-61-9