Pyridine has a conjugated system of six π electrons that are delocalized over the ring. 766-11-0, formula is C5H3BrFN, Name is 5-Bromo-2-fluoropyridine. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Recommanded Product: 5-Bromo-2-fluoropyridine.
Li, Yibiao;Huang, Shuo;Liao, Chunshu;Shao, Yan;Chen, Lu research published 《 Transition-metal-free access to 2-aminopyridine derivatives from 2-fluoropyridines and acetamidine hydrochloride》, the research content is summarized as follows. An efficient method for the synthesis of 2-aminopyridine derivatives I (R = 3-I, 3-Cl-5-I, 5-NO2-6-CH3, etc.; R1 = NH2) through the nucleophilic substitution and hydrolysis of 2-fluoropyridines I (R1 = F) and acetamidine hydrochloride under catalyst-free conditions has been developed. This amination uses inexpensive acetamidine hydrochloride as the ammonia source and has the advantages of high yield, high chemoselectivity and wide substrate adaptability. The results suggest that other N-heterocycles containing fluorine substituents such as 5-chloro-2,4-difluoropyrimidine and 2-fluoropyrazine can also complete the reaction via these reaction conditions and yield the target products 5-chloro-4-fluoropyrimidin-2-amine and pyrazin-2-amine resp.
766-11-0, 5-Bromo-2-fluoropyridine is a useful research compound. Its molecular formula is C5H3BrFN and its molecular weight is 175.99 g/mol. The purity is usually 95%.
5-Bromo-2-fluoropyridine is a boronic acid that has been shown to react with iodides and form 5-bromo-2-fluoroiodobenzene. The reaction of 5-bromo-2-fluoropyridine with benzene gives the same product as the reaction with 1,3,5-trioxane. The UV absorption of 5-bromo-2-fluoropyridine is found at 230 nm and 260 nm. It also has an absorption band in the infrared region at 1625 cm−1. Vibrational progressions have been observed for this molecule, which are due to dipole moments and electron density distributions in the molecule.
5-bromo-2-fluoropyridine is used in the synthesis of heteroaromatic and aniline derivatives of piperidines as potent ligands used for vesicular acetylcholine transport. , Recommanded Product: 5-Bromo-2-fluoropyridine