Li, Yibiao; Huang, Shuo; Liao, Chunshu; Shao, Yan; Chen, Lu published the artcile< Transition-metal-free access to 2-aminopyridine derivatives from 2-fluoropyridines and acetamidine hydrochloride>, Quality Control of 22280-62-2, the main research area is aminopyridine preparation chemoselective green chem; fluoropyridine acetamidine hydrochloride amination.
An efficient method for the synthesis of 2-aminopyridine derivatives I (R = 3-I, 3-Cl-5-I, 5-NO2-6-CH3, etc.; R1 = NH2) through the nucleophilic substitution and hydrolysis of 2-fluoropyridines I (R1 = F) and acetamidine hydrochloride under catalyst-free conditions has been developed. This amination uses inexpensive acetamidine hydrochloride as the ammonia source and has the advantages of high yield, high chemoselectivity and wide substrate adaptability. The results suggest that other N-heterocycles containing fluorine substituents such as 5-chloro-2,4-difluoropyrimidine and 2-fluoropyrazine can also complete the reaction via these reaction conditions and yield the target products 5-chloro-4-fluoropyrimidin-2-amine and pyrazin-2-amine resp.
Organic & Biomolecular Chemistry published new progress about Amination (chemoselective). 22280-62-2 belongs to class pyridine-derivatives, and the molecular formula is C6H7N3O2, Quality Control of 22280-62-2.