Li, Zheng; Xu, Yanqi; Xu, Huandi; Cui, Mengyuan; Liu, Tianguang; Ren, Xiangyu; Sun, Jianfei; Deng, Dawei; Gu, Yueqing; Wang, Peng published their research in Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy in 2021. The article was titled 《A dicyanomethylene-4H-pyran-based fluorescence probe with high selectivity and sensitivity for detecting copper (II) and its bioimaging in living cells and tissue》.Computed Properties of C6H5NO2 The article contains the following contents:
Copper (Cu) plays a significant role in the process of oxygenic photosynthesis in living systems. The detection of copper ion (Cu2+) is valuable and meaningful for further studying the functions of Cu2+ under physiol. and pathol. conditions. A novel fluorescence probe DCM-Cu (I) based on the near-IR (NIR) fluorophore dicyanomethylene-4H-pyran (DCM) was designed for Cu2+ detection. The probe DCM-Cu possessed characteristic of “”turn-on”” fluorescent signal in the presence of Cu2+ through the enhanced ICT process. It exhibited satisfactory sensitivity and selectivity toward Cu2+. A good linear correlation was observed between the concentrations of Cu2+ and the fluorescence intensities at 700 nm. The detection limit (LOD) of DCM-Cu toward Cu2+ is 2.54 × 10-8 M. Importantly, DCM-Cu was successfully applied in the detection of Cu2+ in living MCF-7 cells and tumor tissue with low cytotoxicity. Therefore, this probe would have the potential to monitor cellular Cu2+ in the living system and be applied to the diagnosis of related diseases. In addition to this study using Picolinic acid, there are many other studies that have used Picolinic acid(cas: 98-98-6Computed Properties of C6H5NO2) was used in this study.
Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Computed Properties of C6H5NO2