Li, Zhuang; Cheng, Xian-Yan; Yang, Ning-Yuan; Chen, Ji-Jun; Tang, Wen-Yue; Bian, Jun-Qian; Cheng, Yong-Feng; Li, Zhong-Liang; Gu, Qiang-Shuai; Liu, Xin-Yuan published their research in Organometallics in 2021. The article was titled 《A Cobalt-Catalyzed Enantioconvergent Radical Negishi C(sp3)-C(sp2) Cross-Coupling with Chiral Multidentate N,N,P-Ligand》.Quality Control of 4-Acetylpyridine The article contains the following contents:
A cobalt-catalyzed enantioconvergent radical Negishi C(sp3)-C(sp2) cross-coupling of racemic benzyl chlorides with arylzinc reagents has been developed in good yield with moderate enantioselectivities. This strategy provides an expedient access toward a range of enantioenriched 1,1-diarylmethanes. Key to this discovery is the utilization of a chiral multidentate anionic N,N,P-ligand to strongly coordinate with the cobalt catalyst and tune its chiral environment, thus achieving the enantiocontrol over the highly reactive prochiral alkyl radical species. In the part of experimental materials, we found many familiar compounds, such as 4-Acetylpyridine(cas: 1122-54-9Quality Control of 4-Acetylpyridine)
4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Quality Control of 4-Acetylpyridine