Li, Zi-Qi; Fu, Yue; Deng, Ruohan; Tran, Van T.; Gao, Yang; Liu, Peng; Engle, Keary M. published an article in 2020, the title of the article was Ligand-controlled regiodivergence in nickel-catalyzed hydroarylation and hydroalkenylation of alkenyl carboxylic acids.Safety of 2-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)pyridine And the article contains the following content:
A nickel-catalyzed regiodivergent hydroarylation and hydroalkenylation of unactivated alkenyl carboxylic acids is reported, whereby the ligand environment around the metal center dictates the regiochem. outcome. Markovnikov hydrofunctionalization products are obtained under mild ligand-free conditions, with up to 99% yield and >20:1 selectivity. Alternatively, anti-Markovnikov products can be accessed with a novel 4,4-disubstituted Pyrox ligand I in excellent yield and >20:1 selectivity. Both electronic and steric effects on the ligand contribute to the high yield and selectivity. Mechanistic studies suggest a change in the turnover-limiting and selectivity-determining step induced by the optimal ligand. DFT calculations reveal that in the anti-Markovnikov pathway, repulsion between the ligand and the alkyl group is minimized (by virtue of it being 1° vs. 2°) in the rate- and regioselectivity-determining transmetalation transition state. The experimental process involved the reaction of 2-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)pyridine(cas: 109660-12-0).Safety of 2-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)pyridine
The Article related to hydroarylation regiodivergent alkenyl carboxylic acid boronic acid nickel catalyst, hydroalkenylation regiodivergent alkenyl carboxylic acid boronic acid nickel catalyst, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Carboxylic Acids and Peroxycarboxylic Acids and Their Sulfur-Containing Analogs and Salts and other aspects.Safety of 2-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)pyridine