Supramolecular gel formation regulated by water content in organic solvents: self-assembly mechanism and biomedical applications was written by Liao, Lieqiang;Jia, Xinjian;Lou, Haoxiang;Zhong, Jinlian;Liu, Huijin;Ding, Shunming;Chen, Chao;Hong, Sanguo;Luo, Xuzhong. And the article was included in RSC Advances in 2021.Product Details of 626-64-2 This article mentions the following:
As one of the most important and fruitful methods, supramol. self-assembly has a significant advantage in designing and fabricating functional soft materials with various nanostructures. In this research, a low-mol.-weight gelator, N,N’-di(pyridin-4-yl)-pyridine-3,5-dicarboxamide (PDA-N4), was synthesized and used to construct self-assembled gels via a solvent-mediated strategy. It was found that PDA-N4 could form supramol. gels in mixed solvents of water and DMSO (or DMF) at high water fraction (greater than or equal to 50%). By decreasing the water fraction from 50% to 30%, the gel, suspension and solution phases appeared successively, indicating that self-assembled aggregates could be efficiently modulated via water content in organic solvents. Moreover, the as-prepared PDA-N4 supramol. gels not only displayed solid-like behavior, and pH- and thermo-reversible characteristics, but also showed a solution-gel-crystal transition with the extension of aging time. Further anal. suggested that both the crystal and gel had similar assembled structures. The intermol. hydrogen bonding between amide groups and the 闂?闂?stacking interactions between pyridine groups played key roles in gel formation. Addnl., the release behavior of vitamin B12 (VB12) from PDA-N4 gel (H2O/DMSO, volume/volume = 90/10) was evaluated, and the drug controlled release process was consistent with a first-order release mechanism. The human umbilical venous endothelial cell culture results showed that the PDA-N4 xerogel has good cytocompatibility, which implied that the gels have potential biol. application in tissue engineering and controlled drug release. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Product Details of 626-64-2).
Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of 闂?8.7 闂?10闂? cm3闁荤姾娅ｅΛ纭俵闂?.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ闁荤姾娅ｅΛ纭俵闂? in the liquid phase and 140.4 kJ闁荤姾娅ｅΛ纭俵闂? in the gas phase. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Product Details of 626-64-2