Lisboa, Lynn S.; Riisom, Mie; Vasdev, Roan A. S.; Jamieson, Stephen M. F.; Wright, L. James; Hartinger, Christian G.; Crowley, James D. published an article in 2021. The article was titled 《Cavity-containing [Fe2L3] 4+ helicates: an examination of host-guest chemistry and cytotoxicity》, and you may find the article in Frontiers in Chemistry (Lausanne, Switzerland).Electric Literature of C5H3Br2N The information in the text is summarized as follows:
Two new di(2,2′-bipyridine) ligands, 2,6-bis([2,2′-bipyridin]-5-ylethynyl)pyridine (L1) and bis(4-([2,2′-bipyridin]-5-ylethynyl)phenyl)methane (L2) were synthesized and used to generate two metallosupramol. [Fe2(L)3](BF4)4 cylinders. The ligands and cylinders were characterized using elemental anal., electrospray ionization mass spectrometry, UV-vis, 1H-, 13C and DOSY NMR (NMR) spectroscopies. The mol. structures of the [Fe2(L)3](BF4)4 cylinders were confirmed using X-ray crystallog. Both the [Fe2(L1)3](BF4)4 and [Fe2(L2)3](BF4)4 complexes crystallized as racemic (rac) mixtures of the δδ (P) and λλ (M) helicates. However, 1H NMR spectra showed that in solution the larger [Fe2(L2)3](BF4)4 was a mixture of the rac δδ/λλ and meso-δλ isomers. The host-guest chem. of the helicates, which both feature a central cavity, was examined with several small drug mols. However, none of the potential guests were found to bind within the helicates. In vitro cytotoxicity assays demonstrated that both helicates were active against four cancer cell lines. The smaller [Fe2(L1)3](BF4)4 system displayed low μM activity against the HCT116 (IC50 = 7.1 ± 0.5 μM) and NCI-H460 (IC50 = 4.9 ± 0.4 μM) cancer cells. While the antiproliferative effects against all the cell lines examined were less than the well-known anticancer drug cisplatin, their modes of action would be expected to be very different. The experimental part of the paper was very detailed, including the reaction process of 2,6-Dibromopyridine(cas: 626-05-1Electric Literature of C5H3Br2N)
2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Electric Literature of C5H3Br2N