Pyridine hydrochloride-promoted C-C bond cleavage approach: A metal-free and peroxide-free facile method for the synthesis of amide derivatives was written by Liu, Aqin;Li, Yanwu;Zhang, Xiuyu;Kuang, Qiulin;Li, Suzhen;Liao, Siwei;Huang, Xin;Wang, Yin;Xu, Ping;Wu, Huili;Guo, Mengyi;Ma, Wanqian;Song, Yibo;Hu, Xueyuan;Yuan, Jianyong. And the article was included in Tetrahedron Letters in 2022.Application of 628-13-7 This article mentions the following:
An efficient method for the synthesis of amide derivatives RNHC(O)R1 (R = Ph, 2-OHC6H4, 2-OH-5-MeC6H3, etc.; R1 = Me, Et) by the direct reactions of aromatic amines RNH2 with 1,3-diketones R1C(O)CH2C(O)R2 (R2 = Me, Et, Ph, etc.)promoted by pyridine hydrochloride under metal-free and solvent-free conditions was reported. This transformation was accomplished by cleavage of C-C bond in the presence of pyridine hydrochloride as additive, which excludes the use of transition-metals and harsh reaction conditions. This method has a broad substrate scope and good tolerance for sensitive functional groups. A multi-gram scale reaction is also performed to ensure the scalability of the reaction. In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7Application of 628-13-7).
Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Application of 628-13-7