Controllable deuteration of halogenated compounds by photocatalytic D2O splitting was written by Liu, Cuibo;Chen, Zhongxin;Su, Chenliang;Zhao, Xiaoxu;Gao, Qiang;Ning, Guo-Hong;Zhu, Hai;Tang, Wei;Leng, Kai;Fu, Wei;Tian, Bingbing;Peng, Xinwen;Li, Jing;Xu, Qing-Hua;Zhou, Wu;Loh, Kian Ping. And the article was included in Nature Communications in 2018.Name: 2,3,4,5,6-Perfluoropyridine The following contents are mentioned in the article:
Deuterium labeling is of great value in organic synthesis and the pharmaceutical industry. However, the state-of-the-art C-H/C-D exchange using noble metal catalysts or strong bases/acids suffers from poor functional group tolerances, poor selectivity and lack of scope for generating mol. complexity. Herein, the deuteration of halides using heavy water as the deuteration reagent and porous CdSe nanosheets as the catalyst was demonstrated. The deuteration mechanism involves the generation of highly active carbon and deuterium radicals via photoinduced electron transfer from CdSe to the substrates, followed by tandem radicals coupling process, which is mechanistically distinct from the traditional methods involving deuterium cations or anions. This deuteration strategy showed better selectivity and functional group tolerances than current C-H/C-D exchange methods. Extending the synthetic scope, deuterated boronic acids, halides, alkynes, and aldehydes can be used as synthons in Suzuki coupling, Click reaction, C-H bond insertion reaction etc. for the synthesis of complex deuterated mols. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Name: 2,3,4,5,6-Perfluoropyridine).
2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ路mol鈭? in pyridine vs. 150 kJ路mol鈭? in benzene). Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C鈥揌 in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Name: 2,3,4,5,6-Perfluoropyridine