Regioselective (Diacetoxyiodo)benzene-Promoted Halocyclization of Unfunctionalized Olefins was written by Liu, Gong-Qing;Li, Yue-Ming. And the article was included in Journal of Organic Chemistry in 2014.Recommanded Product: 628-13-7 This article mentions the following:
A metal-free method for intramol. halocyclization of unfunctionalized olefins was detailed. (Diacetoxyiodo)benzene (PIDA) was very effective for haloamidation, haloetherification, and halolactonization of unfunctionalized olefins. E.g., in presence of PIDA and KI in CH2Cl2, intramol. iodoamidation of CH2:CHCH2CPh2CH2NHTs gave 91% pyrrolidine derivative (I). In the presence of 1.1 equiv of PIDA and suitable halogen sources, a variety of unfunctionalized olefins could be converted to the corresponding 1,2-bifunctional cyclic skeletons in good to excellent isolated yields, and key intermediates for biol. interesting compounds could be obtained in high yields under mild conditions via nucleophilic substitution of the thus obtained halocyclization products. In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7Recommanded Product: 628-13-7).
Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Recommanded Product: 628-13-7