Liu, Jianbo; Yuan, Qianjia; Toste, F. Dean; Sigman, Matthew S. published the artcile< Enantioselective construction of remote tertiary carbon-fluorine bonds>, Formula: C13H15F3N2O, the main research area is tertiary benzylic fluoroalkane enantioselective synthesis; enantioselective Heck coupling acyclic alkenyl fluoride arylboronic acid.
The carbon-fluorine bond engenders distinctive physicochem. properties and significant changes to general reactivity. The development of catalytic, enantioselective methods to set stereocenters that contain a benzylic C-F bond is a rapidly evolving goal in synthetic chem. Although there have been notable advances that enable the construction of secondary stereocenters that contain both a C-F and a C-H bond on the same carbon, significantly fewer strategies are defined to access stereocenters that incorporate a tertiary C-F bond, especially those remote from pre-existing activating groups. Here we report a general method that establishes C-F tertiary benzylic stereocenters by forging a C-C bond via a Pd-catalyzed enantioselective Heck reaction of acyclic alkenyl fluorides with arylboronic acids. This method provides a platform to rapidly incorporate significant functionality about the benzylic tertiary fluoride by virtue of the diversity of both reaction partners, as well as the ability to install the stereocenters remotely from pre-existing functional groups.
Nature Chemistry published new progress about Allylic alcohols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 1416819-91-4 belongs to class pyridine-derivatives, and the molecular formula is C13H15F3N2O, Formula: C13H15F3N2O.