Application In Synthesis of 2-BromonicotinaldehydeIn 2020 ,《Elemental Sulfur-Promoted [2+3+1] Annulation for Synthesis of Functionalized Thiochromeno[2,3-b]indoles from Indole Derivatives》 was published in Asian Journal of Organic Chemistry. The article was written by Liu, Jianming; Wang, Zhixian; Wang, Ke; Liu, Dong; Yang, Yan; Fan, Junjun; Zhuo, Kelei; Yue, Yuanyuan. The article contains the following contents:
An intermol. [2+3+1] annulation between indoles I (R1 = H, Me, OMe, Cl, Br; R2 = H, Me, F, OMe, Cl, Br; R3 = H, Me, Cl, F; R4 = H, OMe, Br, Cl) and aromatic aldehyde derivatives 2-Br-3-R5-4-R6-5-R7C6HCHO (R5 = H; R6 = H, Me; R7 = H, F, CF3; R5R6 = -CH=CH-CH=CH-) and 2-bromonicotinaldehyde was successfully achieved by utilizing elemental sulfur as the promoter and coupling partner. This direct and operationally simple procedure provided a rapid and reliable approach to synthesize functionalized thiochromeno[2,3-b]indoles II and pyrido[3′, 2′:5,6]thiopyrano[2, 3-b]indoles III. Preliminary mechanistic studies indicated that elemental sulfur enhanced the nucleophilicity of the 3-position of indole to attack an aldehyde group, and C-H cleavage of indole was not involved in the rate-determining step. The results came from multiple reactions, including the reaction of 2-Bromonicotinaldehyde(cas: 128071-75-0Application In Synthesis of 2-Bromonicotinaldehyde)
2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Application In Synthesis of 2-Bromonicotinaldehyde