Liu, Mao-Chin; Lin, Tai-Shun; Cory, Joseph G.; Cory, Ann H.; Sartorelli, Alan C. published the artcile< Synthesis and Biological Activity of 3- and 5-Amino Derivatives of 2-Pyridinecarboxaldehyde Thiosemicarbazone>, Computed Properties of 56622-54-9, the main research area is Hydrazinecarbothioamide pyridinylmethylene preparation ribonucleoside diphosphate reductase; pyridinecarboxaldehyde thiosemicarbazone preparation ribonucleoside diphosphate reductase; CDP reductase pyridinecarboxaldehyde thiosemicarbazone preparation.
A series of 3- and 5-alkylamino derivatives, as well as other structurally modified analogs of 2-pyridinecarboxaldehyde thiosemicarbazone, were synthesized and evaluated as inhibitors of CDP reductase activity and for their cytotoxicity in vitro and antineoplastic activity in vivo against the L1210 leukemia. Examples of the target compounds were the pyridinecarboxaldehyde thiosemicarbazones I (R = alkyl, allyl). The most biol. active compounds were I (R = Me, Et, allyl), which were potent inhibitors of ribonucleotide reductase with corresponding IC50 values of 1.3, 1.0, and 1.4 μM. The latter compounds produced a significant prolongation of the survival time of L1210 leukemia-bearing mice, with corresponding optimum % T/C values of 223, 204, and 215 when administered twice daily for six consecutive days at dosages of 60, 80, and 80 mg/kg, resp.
Journal of Medicinal Chemistry published new progress about Antitumor agents. 56622-54-9 belongs to class pyridine-derivatives, and the molecular formula is C7H10N2, Computed Properties of 56622-54-9.