Iridium-Catalyzed Highly Enantioselective Transfer Hydrogenation of Aryl N-Heteroaryl Ketones with N-Oxide as a Removable ortho-Substituent was written by Liu, Qixing;Wang, Chunqin;Zhou, Haifeng;Wang, Baigui;Lv, Jinliang;Cao, Lu;Fu, Yigang. And the article was included in Organic Letters in 2018.Recommanded Product: 4-Methylpicolinonitrile This article mentions the following:
A highly enantioselective transfer hydrogenation of non-ortho-substituted aryl N-heteroaryl ketones, using readily available chiral diamine-derived iridium complex as a catalyst and sodium formate as a hydrogen source in a mixture of H2O/i-PrOH (volume/volume = 1:1) under ambient conditions, is described. The chiral aryl N-heteroaryl methanols were obtained with up to 98.2% ee by introducing an N-oxide as a removable ortho-substituent. In contrast, no more than 15.1% ee was observed in the absence of an N-oxide moiety. Furthermore, the practical utility of this protocol was also demonstrated by gram-scale asym. synthesis of bepotastine besilate in 51% total yield and 99.9% ee. In the experiment, the researchers used many compounds, for example, 4-Methylpicolinonitrile (cas: 1620-76-4Recommanded Product: 4-Methylpicolinonitrile).
4-Methylpicolinonitrile (cas: 1620-76-4) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Recommanded Product: 4-Methylpicolinonitrile