Liu, Weiwei; Li, Ruihua; Deng, Fei; Yan, Chunyu; Zhou, Xuelian; Miao, Lu; Li, Xiaolian; Xu, Zhaochao published their research in ACS Applied Bio Materials in 2021. The article was titled 《A Cell Membrane Fluorogenic Probe for Gram-Positive Bacteria Imaging and Real-Time Tracking of Bacterial Viability》.Application In Synthesis of Bis(pyridin-2-ylmethyl)amine The article contains the following contents:
Bacterial infections are a global healthcare problem, resulting in serious clin. morbidities and mortality. Real-time monitoring of live bacteria by fluorescent imaging technol. has potential in diagnosis of bacterial infections, elucidating antimicrobial agents′ mode of action, assessing drug toxicity, and examining bacterial antimicrobial resistance. A naphthalimide-derived fluorescent probe ZTRS-BP was developed for wash-free Gram-pos. bacteria imaging. The probe aggregated in aqueous solutions and exhibited aggregation-caused fluorescence quenching (ACQ). The interaction with Gram-pos. bacteria cell walls would selectively disaggregate the probe and the liberated probes were dispersed on the outside of the bacteria cell walls to achieve surface fluorescence imaging. There were no such interactions with Gram-neg. bacteria, which indicates that selective binding and imaging of Gram-pos. bacteria was achieved. The binding of zinc ions by ZTRS-BP can enhance the fluorescent signals on the bacterial surface by inhibiting the process of photoinduced electron transfer. ZTRS-BP-Zn(II) complex was an excellent dye to discriminate mixed Gram-pos. and Gram-neg. bacteria. Also, live and dead bacteria can be differentially imaged by ZTRS-BP-Zn(II). Furthermore, ZTRS-BP-Zn(II) was used for real-time monitoring bacteria viability such as B. cereus treated with antibiotic vancomycin. In addition to this study using Bis(pyridin-2-ylmethyl)amine, there are many other studies that have used Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Application In Synthesis of Bis(pyridin-2-ylmethyl)amine) was used in this study.
Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. As a tridentate ligand this compound provides three nitrogen donors that affords good selectivity for Zn2+ over biologically relevant metals such as Na+, K+, Mg2+ and Ca2+, and leaves coordination sites free for anion binding. Application In Synthesis of Bis(pyridin-2-ylmethyl)amine