Liu, Yan-Hua; Xie, Pei-Pei; Liu, Lei; Fan, Jun; Zhang, Zhuo-Zhuo; Hong, Xin; Shi, Bing-Feng published their research in Journal of the American Chemical Society in 2021. The article was titled 《Cp*Co(III)-Catalyzed Enantioselective Hydroarylation of Unactivated Terminal Alkenes via C-H Activation》.Application of 3510-66-5 The article contains the following contents:
Enantioselective hydroarylation of unactivated terminal alkenes RCH=CH2 (R = n-hexyl, benzyl, cyclohexylmethyl, etc.) constitutes a prominent challenge in organic chem. Synthesis of Cp*Co(III)-catalyzed asym. hydroarylation of unactivated aliphatic terminal alkenes assisted by a new type of tailor-made amino acid ligands. Critical to the chiral induction was the engaging of a novel noncovalent interaction (NCI), which has seldomly been disclosed in C-H activation area, arising from the mol. recognition among the organocobalt(III) intermediate, the coordinated alkene and the well-designed chiral ligand. A broad range of C2 alkylated indoles were obtained in high yields and excellent enantioselectivities. DFT calculations revealed the reaction mechanism and elucidated the origins of chiral induction in the stereodetermining alkene insertion step. The results came from multiple reactions, including the reaction of 2-Bromo-5-methylpyridine(cas: 3510-66-5Application of 3510-66-5)
2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Application of 3510-66-5