At 25 °C pyridine has a viscosity of 0.88 mPa/s and thermal conductivity of 0.166 W·m−1·K−1. 16133-25-8, formula is C5H4ClNO2S, Name is Pyridine-3-sulfonyl chloride. The enthalpy of vaporization is 35.09 kJ·mol−1 at the boiling point and normal pressure.The enthalpy of fusion is 8.28 kJ·mol−1 at the melting point. Application In Synthesis of 16133-25-8.
Liu, Yishuai;Zhu, Haibo;Yang, Liu;Xie, Zongbo;Jiang, Guofang;Le, Zhang-Gao;Tu, Tao research published 《 Transition-Metal-Free Approaches to Arylsulfones using Benzylic Ammonium Salts through C-N Bond Cleavage》, the research content is summarized as follows. A transition-metal-free approach to benzyl sulfones I (R1 = 2-Me, 4-Me, 4-MeO, etc.; R2 = H, 3-Me, 4-tBu, etc.) by using sodium sulfinates and benzyl ammonium salts is described. The protocol provides a simple and direct method to realize the C-N bond cleavage in the presence of readily available Cs2CO3. During the reaction process, a range of functional groups with respect to both sodium sulfinates and benzylic ammonium salts were well compatible, leading to various benzyl sulfones in moderate to good yields.
Application In Synthesis of 16133-25-8, Pyridine-3-sulfonyl chloride is a useful research compound. Its molecular formula is C5H4ClNO2S and its molecular weight is 177.61 g/mol. The purity is usually 95%.
Pyridine-3-sulfonyl chloride is a reagent used in the synthesis of pyrimidine derivatives with anti-proliferative activity against negative breast cancer cells.
Pyridine-3-sulfonyl chloride is a chemical compound that binds to the active site of cytochrome P450 enzymes. It can be used to study the effects of matrix effect on reaction solution. Pyridine-3-sulfonyl chloride has been shown to have an UV absorption spectrum with a maximum at 280 nm and a p450 activity that is proportional to the concentration of human serum. This compound has been shown to inhibit kinase domain in vitro assays, which may have clinical relevance in the treatment of obesity., 16133-25-8.