Lombardini, J. B. published the artcileAnalogs of taurine as inhibitors of the phosphorylation of an â?0 K molecular weight protein present in a mitochondrial fraction of the rat retina, SDS of cas: 636-73-7, the publication is Amino Acids (1997), 13(2), 115-130, database is CAplus.
It was previously demonstrated that taurine inhibits the phosphorylation of a â?0 K apparent mol. weight protein present in the mitochondrial fraction of the rat retina. Analogs of taurine were tested for their inhibitory activity on the phosphorylation of this 20 K protein. The most potent analogs were (±)trans-2-aminocyclopentanesulfonic acid (TAPS) and 1,2,3,4-tetrahydroquinoline-8-sulfonic acid (THQS), which were 21 and 7 times more potent than the parent compound, taurine, resp. Median-effect plots were used to calculate the inhibitory median effect and combination index values for the combined effects of taurine and taurine analogs. It was determined that the inhibitory taurine analogs were antagonistic to taurine when used in combination with taurine to inhibit the phosphorylation of the 20 K apparent mol. weight protein. It was concluded that the distance between the N and S atoms in the taurine structure was important for inhibitory activity. If the N atom was either within or attached to an unsaturated ring structure, the inhibitory potency was decreased. If both the S and N atoms were present within the ring structure, the analog has no activity.
Amino Acids published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, SDS of cas: 636-73-7.
Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem