How Aromatic Fluorination Exchanges the Interaction Role of Pyridine with Carbonyl Compounds: The Formaldehyde Adduct was written by Lopez, Juan Carlos;Macario, Alberto;Maris, Assimo;Alkorta, Ibon;Blanco, Susana. And the article was included in Chemistry – A European Journal in 2021.Synthetic Route of C5F5N The following contents are mentioned in the article:
The rotational spectrum of the weakly bound complex pentafluoropyridine路路路formaldehyde has been investigated using Fourier transform microwave spectroscopy. From the anal. of the rotational parameters of the parent species and of the 13C and 15N isotopologs, the structural arrangement of the adduct has been unambiguously established. The full ring fluorination of pyridine has a dramatic effect on its binding properties: It alters the electron d. distribution at the 蟺-cloud of pyridine creating a 蟺-hole and changing its electron donor-acceptor capabilities. In the complex, formaldehyde lies above the aromatic ring with one of the oxygen lone pairs, as conventionally envisaged, pointing toward its center. This lone pair路路路蟺-hole interaction, reinforced by a weak C-H路路路N interaction, indicates an exchange of the electron-acceptor roles of both mols. when compared to the pyridine路路路formaldehyde adduct. Tunnelling doublets due to the internal rotation of formaldehyde have also been observed and analyzed leading to a discussion on the competition between lone pair路路路蟺-hole and 蟺路路路蟺 stacking interactions. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Synthetic Route of C5F5N).
2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C鈥揌 in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Synthetic Route of C5F5N