Louw, Stefan published the artcileHigh-efficiency hydrophilic interaction chromatography by coupling 25 cm × 4.6 mm ID × 5 μm silica columns and operation at 80°C, Safety of 4-Amino-2-picoline, the publication is Journal of Chromatography A (2010), 1217(4), 514-521, database is CAplus and MEDLINE.
Recently, hydrophilic interaction chromatog. (HILIC) has emerged as a valuable orthogonal tool to reversed-phase liquid chromatog. (RP-LC) as it allows for resolution of highly polar ionisable compounds The relationships between separation efficiency, column length and speed of anal. for 4.6 mm ID × 5 μm silica particle columns in HILIC are demonstrated using kinetic plots. The kinetic plots constructed for conventional pressure systems operating at 350 bar and at 30° and 80° are confirmed using exptl. data for different column lengths. Efficiencies of more than 130,000 theor. plates could be achieved by connecting up to six columns of 25 cm. As expected, a significant gain in anal. speed without loss of efficiency could be obtained by operating at 80° compared to 30°. The advantages of using long columns in HILIC in combination with elevated column temperature for the pharmaceutical industry are illustrated using test mixtures comprised of com. available ionisable compounds (including some containing functional groups with potential genotoxic typical structural alerts) as well as real polar ionisable pharmaceuticals.
Journal of Chromatography A published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C6H8N2, Safety of 4-Amino-2-picoline.
Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem