Lu, Yang published the artcileEnhanced felodipine dissolution from high drug loading amorphous solid dispersions with PVP/VA and sodium dodecyl sulfate, Application In Synthesis of 72509-76-3, the main research area is felodipine dissolution amorphous solid dispersion sodium dodecyl sulfate PVP.
The objective of this study was to investigate the mechanisms of sodium dodecyl sulfate (SDS) and Copovidone (PVP/VA) enhancing the dissolution of high loaded felodipine (FLDP) amorphous extrudates. The rheol. results indicated that PVP/VA inhibited FLDP crystallization and the binary FLDP-PVP/VA (1:1 and 1:3) and ternary FLDP-PVP/VA-SDS (1:1:0.02-0.16 and 1:3:0.02-0.32) extrudates were amorphous solid dispersions (ASDs). Internal SDS (5%-20%) decreased glass transition temperature (Tgs) of FLDP-PVP/VA ternary ASDs. The enhanced dissolution rate of binary or ternary PVP/VA-rich ASDs in the non-sink condition of 0.05%SDS was achieved. SDS enhanced the dissolution of PVP/VA-rich ASDs via wettability and complexation with PVP/VA to accelerate the medium uptake and erosion kinetics of extrudates, but induced FLDP recrystallization and resulted in incomplete dissolution of FLDP-rich extrudates. Interestingly, when the ratio of FLDP-SDS was 1:0.08-0.12, the addition of SDS can significantly promote drug dissolution To confirm the in vitro relevance of these mol. interaction mechanisms, we prepared two tablet formulations which internal or external added SDS, resp., the ratio of FLDP-SDS was 1:0.1. The results show that SDS can promote the dissolution of FLDP when only SDS was internal added.
Journal of Drug Delivery Science and Technology published new progress about Absorption. 72509-76-3 belongs to class pyridine-derivatives, name is 3-Ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C18H19Cl2NO4, Application In Synthesis of 72509-76-3.