Base-promoted relay reaction of heterocyclic ketene aminals with o-difluorobenzene derivatives for the highly site-selective synthesis of functionalized indoles was written by Luo, Da-Yun;Hu, Xing-Mei;Huang, Rong;Cui, Shi-Sheng;Yan, Sheng-Jiao. And the article was included in Tetrahedron in 2021.Recommanded Product: 2,3,4,5,6-Perfluoropyridine The following contents are mentioned in the article:
A novel method was developed for the construction of highly functionalized indole derivatives, including fluorinated indoles I (R = H, F, CN, NO2; R1 = H, F, NO2, CN; R2 = H, F, methoxycarbonyl; R3 = H, F CN; R4 = NO2, benzoyl, (4-chlorophenyl)carbonyl, (thiophen-2-yl)carbonyl, etc.; Z = CH, N), via a site-selective, one-pot, two-step nucleophilic aromatic substitution reaction of o-difluorobenzene derivatives II with heterocyclic ketene aminals (HKAs) III promoted by two different bases (K2CO3 and Cs2CO3). A diverse library of indoles I was generated in good to excellent yields using a conventional base-mediated approach rather than metal catalysts. As a result, the highly functionalized indoles I were easily obtained in an environmentally friendly, rapid, and practical manner, and the products have potential biol. activity. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Recommanded Product: 2,3,4,5,6-Perfluoropyridine).
2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Pyridine derivatives are also useful as small-molecule 伪-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Recommanded Product: 2,3,4,5,6-Perfluoropyridine