Luo, Dexia; Guo, Shengxin; He, Feng; Chen, Shunhong; Dai, Ali; Zhang, Renfeng; Wu, Jian published an article in Journal of Agricultural and Food Chemistry. The title of the article was 《Design, Synthesis, and Bioactivity of α-Ketoamide Derivatives Bearing a Vanillin Skeleton for Crop Diseases》.Safety of 4-Amino-2-picoline The author mentioned the following in the article:
A series of novel α-ketoamide derivatives bearing a vanillin skeleton were designed and synthesized. Bioactivity tests on virus and bacteria were performed. The results indicated that some compounds exhibited excellent antitobacco mosaic virus (TMV) activities, such as compound I exhibited an inactivation activity of 90.1% and curative activity of 51.8% and compound II exhibited a curative activity of 54.8% at 500μg mL-1, which is equivalent to that of the com. ningnanmycin (inactivation of 91.9% and curative of 51.9%). Moreover, the in vitro antibacterial activity test illustrated that compounds showed much higher activities than com. thiodiazole copper, which could be used as lead compounds or potential candidates. The findings of transmission electron microscopy and mol. docking indicated that the synthesized compounds exhibited strong and significant binding affinity to the TMV coat protein and could obstruct the self-assembly and increment of TMV particles. This study revealed that α-ketoamide derivatives bearing a vanillin skeleton could be used as a novel potential pesticide for controlling the plant diseases. In the part of experimental materials, we found many familiar compounds, such as 4-Amino-2-picoline(cas: 18437-58-6Safety of 4-Amino-2-picoline)
4-Amino-2-picoline(cas: 18437-58-6) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Safety of 4-Amino-2-picoline