《Ligand-free copper-catalyzed regio- and stereoselective 1,1-alkylmonofluoroalkylation of terminal alkynes》 was written by Lv, Yunhe; Pu, Weiya; Wang, Xiaoxing. Category: pyridine-derivatives And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020. The article conveys some information:
The copper-catalyzed highly regio- and stereoselective 1,1-alkylmonofluoroalkylation of terminal alkynes with α-chloroacetamides and dialkyl 2-fluoromalonate or 2-fluoro-N,N-dialkyl-3-oxobutanamide without an external ligand was realized. With this novel methodol., (E)-β-monofluoroalkyl-β,γ-unsaturated amides containing quaternary C-F centers I [R = CH2OMe, 3-thienyl, Ph, etc.] could be easily constructed in good to excellent yields. The experimental part of the paper was very detailed, including the reaction process of 4-Ethynylpyridine(cas: 2510-22-7Category: pyridine-derivatives)
4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Category: pyridine-derivatives