《Design, synthesis and biological evaluation of 4-aryl-5-aminoalkyl-thiazole-2-amines derivatives as ROCK II inhibitors》 was published in Bioorganic & Medicinal Chemistry in 2020. These research results belong to Ma, Shuchao; Wang, Linan; Ouyang, Ben; Fan, Meixia; Qi, Junhui; Yao, Lei. Synthetic Route of C7H7NO The article mentions the following:
A series of 4-aryl-5-aminoalkyl-thiazole-2-amines I (n = 0, 1, 2; X = N, CH; Y = N, CH; R = N,N-dimethylcarbamoyl, morpholin-4-yl, 4-methylpiperazin-1-yl, etc.; R1 = pyridin-4-yl, pyridin-3-yl, 2,3-dihydro-1,4-benzodioxin-2-yl) was designed and synthesized, and their inhibitory activity on ROCK II was screened by ELISA (ELISA). The results showed that 4-aryl-5-aminomethyl-thiazole-2-amines derivatives I had certain ROCK II inhibitory activities. Compound I (n = 1; X = N; Y = CH; R = morpholin-4-yl; R1 = 2,3-dihydro-1,4-benzodioxin-2-yl) showed ROCK II inhibitory activity with IC50 value of 20 nM.4-Acetylpyridine(cas: 1122-54-9Synthetic Route of C7H7NO) was used in this study.
4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Synthetic Route of C7H7NO