Ma, Xiangyu published the artcileInfluence of mechanical and thermal energy on nifedipine amorphous solid dispersions prepared by hot melt extrusion: Preparation and physical stability, Application In Synthesis of 21829-25-4, the main research area is nifedipine amorphous solid dispersion extrusion stability; Amorphous solid dispersion; Homogeneity; Hot melt extrusion; Physical stability; Specific mechanical energy; Thermal energy.
Hot melt extrusion (HME) has been used to prepare solid dispersions, especially molecularly dispersed amorphous solid dispersions (ASDs) for solubility enhancement purposes. The energy generated by the extruder in the form of mech. and thermal output enables the dispersion and dissolution of crystalline drugs in polymeric carriers. However, the impact of this thermal and mech. energy on ASD systems remains unclear. We selected a model ASD system containing nifedipine (NIF) and polyvinylpyrrolidone vinyl acetate (PVP/VA 64) to investigate how different types of energy input affect the preparation and phys. stability of ASDs. Formulations were prepared using a Leistritz Nano-16 extruder, and we varied the screw design, barrel temperature, screw speed, and feed rate to control the mech. and thermal energy input. Specific mech. energy (SME) was calculated to quantitate the mech. energy input, and the thermal energy was estimated using barrel temperature We find that both mech. and thermal energy inputs affect the conversion of crystalline NIF into an amorphous form, and they also affect the level of mixing and the degree of homogeneity in NIF ASDs. However, for small size extruders (e.g., Leistritz Nano-16), thermal energy is more efficient than mech. energy in preparing NIF ASDs that have better stability.
International Journal of Pharmaceutics (Amsterdam, Netherlands) published new progress about Amorphous materials. 21829-25-4 belongs to class pyridine-derivatives, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C17H18N2O6, Application In Synthesis of 21829-25-4.