Ma, Zhuang; Lu, Helin; Liao, Ke; Chen, Zhilong published the artcile< Tungstate-Catalyzed Biomimetic Oxidative Halogenation of (Hetero)Arene under Mild Condition>, Recommanded Product: 3-Bromo-1H-pyrrolo[3,2-c]pyridine, the main research area is arene metal halide tungstate catalyst regioselective chemoselective oxidative halogenation; haloarene preparation green chem; Green Chemistry; Organic Chemistry; Pharmaceutical Engineering.
A biomimetic approach for halogenation (Br, Cl, I) of (hetero)arene catalyzed by tungstate under mild pH in a cost-efficient and environment- and operation-friendly manner was reported. Broad substrates diverse functional group tolerance and good chemo- and regioselectivities were observed, even in late-stage halogenation of complex mols. Moreover, this approach was scaled up to over 100 g without time-consuming and costly column purification Several drugs and key precursors for drugs bearing aryl halides (Br, Cl, I) was conveniently prepared based on this approach.
iScience published new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent). 23612-36-4 belongs to class pyridine-derivatives, and the molecular formula is C7H5BrN2, Recommanded Product: 3-Bromo-1H-pyrrolo[3,2-c]pyridine.