Mahmoudi, Maedeh; Bayat, Amir-Hossein; Boroujeni, Mahdi Eskandarian; Abdollahifar, Mohammad Amin; Ebrahimi, Vahid; Danyali, Samira; Heidari, Mohammad Hassan; Aliaghaei, Abbas published the artcile< Curcumin protects purkinje neurons, ameliorates motor function and reduces cerebellar atrophy in rat model of cerebellar ataxia induced by 3-AP>, Recommanded Product: 1-(Pyridin-3-yl)ethanone, the main research area is cerebellar ataxia purkinje neuron curcumin motor function; 3-Acethylpyridine; Cerebellar ataxia; Curcumin; Neuroprotection; Purkinje cells.
Cerebellar ataxias comprise a group of terminal illnesses with ataxia as the main symptom. Curcumin as a yellow polyphenol was extracted from the rhizome of Curcuma longa. Owing to its antioxidant, anti-inflammatory, anti-fibrotic and anti-tumor features, curcumin is considered as a potential therapeutic agent. In this study, we aim to investigate the neuroprotective effects of oral administration of curcumin on a rat model of cerebellar ataxia induced by neurotoxin 3-acetylpyridine. The animals were randomly separated into three groups (control, 3-acetylpyridine, and curcumin + 3-acetylpyridine). Next, motor performance and muscle electromyog. activity were assessed. Then, in the mol. part of the study, the anti-apoptotic role of curcumin in cerebellar ataxia and its relationship to protection of Purkinje cells were investigated. Curcumin treatment improved motor coordination and muscular activity, reduced cleaved caspase-3, and increased glutathione level in 3-AP-lesioned rats as well as total volumes of cerebellar granular and mol. layers.the present study implies that curcumin might have neuroprotective effects to counteract neurotoxicity of 3-AP-induced ataxia.
Journal of Chemical Neuroanatomy published new progress about Electromyography. 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Recommanded Product: 1-(Pyridin-3-yl)ethanone.