In 2022,Makarian, Makar; Gonzalez, Michael; Salvador, Stephanie M.; Lorzadeh, Shahrokh; Hudson, Paula K.; Pecic, Stevan published an article in Journal of Molecular Structure. The title of the article was 《Synthesis, kinetic evaluation and molecular docking studies of donepezil-based acetylcholinesterase inhibitors》.Computed Properties of C6H4BrNO The author mentioned the following in the article:
In an effort to develop new therapeutic agents to treat Alzheimer′s disease, a series of donepezil-based analogs were designed, synthesized using an environmentally friendly route, and biol. evaluated for their inhibitory activity against elec. eel acetylcholinesterase (AChE) enzyme. In vitro studies revealed that the Ph moiety of donepezil can be successfully replaced with a pyridine ring leading to equally potent inhibitors of elec. eel AChE. Further kinetic evaluations of the most potent inhibitor showed a dual-binding (mixed inhibition) mode, similar to donepezil. Mol. modeling studies suggest that several addnl. residues could be involved in the binding of this inhibitor in the human AChE enzyme active site compared to donepezil. The experimental part of the paper was very detailed, including the reaction process of 2-Bromonicotinaldehyde(cas: 128071-75-0Computed Properties of C6H4BrNO)
2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Computed Properties of C6H4BrNO