Malamas, Michael S. et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2012 | CAS: 6980-09-2

2-Chloro-4-methoxy-3-nitropyridine (cas: 6980-09-2) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Quality Control of 2-Chloro-4-methoxy-3-nitropyridine

Novel triazines as potent and selective phosphodiesterase 10A inhibitors was written by Malamas, Michael S.;Stange, Hans;Schindler, Rudolf;Lankau, Hans-Joachim;Grunwald, Christian;Langen, Barbara;Egerland, Ute;Hage, Thorsten;Ni, Yike;Erdei, James;Fan, Kristi Yi;Parris, Kevin;Marquis, Karen L.;Grauer, Steve;Brennan, Julie;Navarra, Rachel;Graf, Radka;Harrison, Boyd L.;Robichaud, Albert;Kronbach, Thomas;Pangalos, Menelas N.;Brandon, Nicholas J.;Hoefgen, Norbert. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2012.Quality Control of 2-Chloro-4-methoxy-3-nitropyridine This article mentions the following:

The identification of highly potent and orally active triazines for the inhibition of PDE10A is reported. The new analogs exhibit low-nanomolar potency for PDE10A, demonstrate high selectivity against all other members of the PDE family, and show desired drug-like properties. Employing structure-based drug design approaches, the authors investigated the selectivity of PDE10A inhibitors against other known PDE isoforms, by methodically exploring the various sub-regions of the PDE10A ligand binding pocket. A systematic assessment of the ADME and pharmacokinetic properties of the newly synthesized compounds has led to the design of drug-like candidates with good brain permeability and desirable drug kinetics (t1/2, bioavailability, clearance). Compound I was highly potent for PDE10A (IC50 = 1.4 nM), demonstrated high selectivity (>200闂? for the other PDEs, and was efficacious in animal models of psychoses; reversal of MK-801 induced hyperactivity (MED = 0.1 mg/kg) and conditioned avoidance responding (CAR; ID50 = 0.2 mg/kg). In the experiment, the researchers used many compounds, for example, 2-Chloro-4-methoxy-3-nitropyridine (cas: 6980-09-2Quality Control of 2-Chloro-4-methoxy-3-nitropyridine).

2-Chloro-4-methoxy-3-nitropyridine (cas: 6980-09-2) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Quality Control of 2-Chloro-4-methoxy-3-nitropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem