《Chiral Hexahalogenated 4,4′-Bipyridines》 was written by Mamane, V.; Peluso, P.; Aubert, E.; Cossu, S.; Pale, P.. Name: 5-Bromo-2-chloropyridineThis research focused ontrihalopyridine dimerization; bipyridinedione regioselective halogenation copper Finkelstein reaction catalyst; bipyridine hexahalogenated preparation kinetic resolution; chiral hexahalogenated bipyridine preparation. The article conveys some information:
The preparation of 27 isomers of chiral hexahalogeno-4,4′-bipyridines by means of two complementary methods is described. The first one is convergent and based on the LDA-induced 4,4′-dimerization of trihalopyridines, whereas the second method is divergent and achieved through regioselective halogenation reactions of 4,4′-bipyridine-2,2′-diones. Iodine in 2,2′-positions of the 4,4′-bipyridines was introduced by a copper-catalyzed Finkelstein reaction (Buchwald procedure) performed on 2,2′-dibromo derivatives Selected compounds of this new family of atropisomeric 4,4′-bipyridines were enantiosepd. by high performance liquid chromatog. on chiral stationary phases, and the absolute configurations of the separated enantiomers were assigned by using X-ray diffraction anal. The latter revealed that various halogen bond types are responsible for crystal cohesion. In the experiment, the researchers used 5-Bromo-2-chloropyridine(cas: 53939-30-3Name: 5-Bromo-2-chloropyridine)
5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Name: 5-Bromo-2-chloropyridine