Mangas-Sanchez, Juan; Sharma, Mahima; Cosgrove, Sebastian C.; Ramsden, Jeremy I.; Marshall, James R.; Thorpe, Thomas W.; Palmer, Ryan B.; Grogan, Gideon; Turner, Nicholas J. published the artcile< Asymmetric synthesis of primary amines catalyzed by thermotolerant fungal reductive aminases>, Category: pyridine-derivatives, the main research area is ketone ammonia fungal aminase catalyst enantioselective reductive amination; amine preparation.
The structural and biochem. characterization as well as synthetic applications of two RedAms from Neosartorya spp. was described. (NfRedAm and NfisRedAm) that displayed a distinctive activity amongst fungal RedAms, namely a superior ability to use ammonia as the amine partner. Using these enzymes, The synthesis of a broad range of primary amines, with conversions up to >97% and excellent enantiomeric excess was demonstrated . Temperature dependent studies showed that these homologues also possess greater thermal stability compared to other enzymes within this family. Their synthetic applicability was further demonstrated by the production of several primary and secondary amines with turnover numbers (TN) up to 14 000 as well as continous flow reactions, obtaining chiral amines such as (R)-2-aminohexane in space time yields up to 8.1 g L-1 h-1. The remarkable features of NfRedAm and NfisRedAm highlight their potential for wider synthetic application as well as expanding the biocatalytic toolbox available for chiral amine synthesis.
Chemical Science published new progress about Amines Role: BPN (Biosynthetic Preparation), RCT (Reactant), BIOL (Biological Study), PREP (Preparation), RACT (Reactant or Reagent). 350-03-8 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO, Category: pyridine-derivatives.