Manley, Peter J.’s team published research in Bioorganic & Medicinal Chemistry Letters in 13 | CAS: 18437-58-6

Manley, Peter J. published the artcile2,4-Disubstituted pyrimidines: A novel class of KDR kinase inhibitors, Safety of 4-Amino-2-picoline, the publication is Bioorganic & Medicinal Chemistry Letters (2003), 13(10), 1673-1677, database is CAplus and MEDLINE.

2,4-Disubstituted pyrimidines were synthesized as a novel class of KDR kinase inhibitors. Evaluation of the SAR of the screening lead compound I (R = H) (KDR IC₅₀=105 nM, Cell IC₅₀=8% inhibition at 500 nM) led to the potent 3,5-dimethylaniline derivative I (R = Me) (KDR IC₅₀=6 nM, cell IC₅₀=19 nM).

Bioorganic & Medicinal Chemistry Letters published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C6H8N2, Safety of 4-Amino-2-picoline.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem