Synthesis and fungicidal activity of novel methoximinoacetates containing phenylpyridine moieties was written by Mao, Dajie;Hu, Chongbo;Liu, Jianhua;Du, Xiaohua;Xu, Zhenyuan. And the article was included in Nongyaoxue Xuebao in 2014.Safety of 2-Bromo-3-(trifluoromethyl)pyridine This article mentions the following:
Twenty-four novel methoximinoacetate compounds containing phenylpyridine moieties were synthesized from (3-hydroxyphenyl) boronic acid and substituted bromopyridines via Suzuki cross-coupling reaction and nucleophilic substitution. The structures of all compounds were confirmed by 1H-NMR, ESI-MS and IR. Bioactivity tests showed that most of the compounds had moderate to good fungicidal activity and compounds 5i, 5r and 5t exhibited more than 80% inhibition against Pseudoperonospora cubensis at 50 mg/L, which meant that the title compounds were potential as the fungicidal lead compounds In the experiment, the researchers used many compounds, for example, 2-Bromo-3-(trifluoromethyl)pyridine (cas: 175205-82-0Safety of 2-Bromo-3-(trifluoromethyl)pyridine).
2-Bromo-3-(trifluoromethyl)pyridine (cas: 175205-82-0) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Safety of 2-Bromo-3-(trifluoromethyl)pyridine