In 2008,Martin, Thibaut; Verrier, Cecile; Hoarau, Christophe; Marsais, Francis published 《Direct C-2 arylation of alkyl 4-thiazolecarboxylates: new insights in synthesis of heterocyclic core of thiopeptide antibiotics》.Organic Letters published the findings.Application of 29682-15-3 The information in the text is summarized as follows:
The Pd(0)-catalyzed regioselective C-2 (hetero)arylation of tert-Bu 4-thiazolecarboxylate with a broad (hetero)aryl halide is reported, including the direct coupling of pyridinyl halides. The process has allowed the preparation of valuable 2-pyridynyl-4-thiazolecarboxylates which are components of the complex heterocyclic core of thiopeptides antibiotics. As a first application, a synthesis of a tert-Bu sulfomycinamate thio-analog from tert-Bu 4-thiazolecarboxylate is here described through a three-step direct pyridinylation, halogenation, and Stille cross-coupling sequence.Methyl 5-bromopicolinate(cas: 29682-15-3Application of 29682-15-3) was used in this study.
Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Application of 29682-15-3