Marugan, Juan Jose; Huang, Wenwei; Motabar, Omid; Zheng, Wei; Xiao, Jingbo; Patnaik, Samarjit; Southall, Noel; Westbroek, Wendy; Lea, Wendy A.; Simeonov, Anton; Goldin, Ehud; DeBernardi, Maria A.; Sidransky, Ellen published an article in 2012, the title of the article was Non-iminosugar glucocerebrosidase small molecule chaperones.Recommanded Product: N1-(5-Bromopyrid-2-yl)ethane-1,2-diamine And the article contains the following content:
Small mol. chaperones are a promising therapeutic approach for the Lysosomal Storage Disorders (LSDs). Here, we report the discovery of a new series of non-iminosugar glucocerebrosidase inhibitors with chaperone capacity, and describe their structure-activity relationship (SAR), selectivity, cell activity and pharmacokinetics. The experimental process involved the reaction of N1-(5-Bromopyrid-2-yl)ethane-1,2-diamine(cas: 199522-66-2).Recommanded Product: N1-(5-Bromopyrid-2-yl)ethane-1,2-diamine
The Article related to glucocerebrosidase inhibitor chaperone pharmacokinetics brain ml156 msbar, Pharmacology: Structure-Activity and other aspects.Recommanded Product: N1-(5-Bromopyrid-2-yl)ethane-1,2-diamine