Novel heteroaryl replacements of aromatic 3-tetrafluoroethoxy substituents in trifluoro-3-(tertiary amino)-2-propanols as potent inhibitors of cholesteryl ester transfer protein was written by Massa, M. A.;Spangler, D. P.;Durley, R. C.;Hickory, B. S.;Connolly, D. T.;Witherbee, B. J.;Smith, M. E.;Sikorski, J. A.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2001.Related Products of 175205-82-0 This article mentions the following:
A series of novel N,N-disubstituted trifluoro-3-amino-2-propanols, e.g., I, has been prepared as potent inhibitors of cholesteryl ester transfer protein. Modifying the aromatic 3-tetrafluoroethoxy group in the lead mol. (II) with various heteroaryl moieties produced new 2-furyl analogs with submicromolar potency in vitro. In the experiment, the researchers used many compounds, for example, 2-Bromo-3-(trifluoromethyl)pyridine (cas: 175205-82-0Related Products of 175205-82-0).
2-Bromo-3-(trifluoromethyl)pyridine (cas: 175205-82-0) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Related Products of 175205-82-0