On November 25, 2010, Maue, Michael; Adelt, Isabelle; Giencke, Wolfgang; Heil, Markus; Jeschke, Peter; Kapferer, Tobias; Krueger, Bernd-Wieland; Muehltau, Friedrich August; Sudau, Alexander; Adamczewski, Martin; Drewes, Mark Wilhelm; Ebbinghaus-Kintscher, Ulrich; Raming, Klaus; Voerste, Arnd; Franken, Eva-Maria; Becker, Angela; Goergens, Ulrich published a patent.Synthetic Route of 1227002-03-0 The title of the patent was Preparation of halogen-substituted compounds as pesticides. And the patent contained the following:
The invention relates to halogen-substituted compounds of formula I and to the use of these compounds for controlling animal pests. The invention furthermore relates to processes and intermediates for the preparation of the compounds of the formula I. Compounds of formula I wherein R1 is H, (un)substituted C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, etc.; A1 is CR2, G, G-amino, G-oxy and G-thio; A2 is CR3, G, G-amino, G-oxy and G-thio; A4 is CR4, G, G-amino, G-oxy and G-thio; A5 is CR5, G, G-amino, G-oxy and G-thio; R2, R3, R4 and R5 are independently H, halo, CN, NO2, (un)substituted C1-6 alkyl, etc.; G is H, (un)substituted C1-6 alkyl, C1-4 alkenyl, C1-4 alkynyl, C1-6 haloalkyl, etc.; U is CO, CS, SO and SO2; L is CONH, and derivatives, and CONHSO2; Q is (un)substituted Ph and (un)substituted pyridinyl; T is substituted thienyl, substituted azolyl, substituted furanyl, etc.; m is 1; are claimed. Example compound II was prepared by chlorination of 2-pentafluoroethyl-4-trifluoromethylpyrimidine-5-carboxylic acid; the resulting 2-pentafluoroethyl-4-trifluoromethylpyrimidine-5-carbonyl chloride underwent amidation with 5-amino-2-chloro-N-(3-chlorophenyl)benzamide to give compound II. All the invention compounds were evaluated for their pesticidal activity (some data given). The experimental process involved the reaction of Methyl 2-amino-5-chloroisonicotinate(cas: 1227002-03-0).Synthetic Route of 1227002-03-0
The Article related to halogen substituted compound preparation pesticide, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Synthetic Route of 1227002-03-0