Application In Synthesis of 2-Bromopyridin-3-amineOn March 9, 2022, Maust, Mark C.; Hendy, Cecilia M.; Jui, Nathan T.; Blakey, Simon B. published an article in Journal of the American Chemical Society. The article was 《Switchable Regioselective 6-endo or 5-exo Radical Cyclization via Photoredox Catalysis》. The article mentions the following:
Here a simple method for reagent controlled regioselective radical cyclization of halogenated N-heterocycles onto pendant olefins was developed. Radical generation occurs under mild photoredox conditions with control of the regioselectivity governed by the rate of hydrogen atom transfer (HAT). Utilizing a polarity-matched thiol-based HAT agent promoted the highly selective formation of the 5-exo cyclization product. Conversely, limiting the solubility of the HAT reagent Hantzsch ester (HEH) leads to selective formation of the thermodynamically favored 6-endo product. This occurs through an initial 5-exo cyclization, with the resulting alkyl radical intermediate undergoing neophyl rearrangement to form the 6-endo product. Development of this switchable catalysis strategy allows for two modes of divergent reactivity to form either the 6-endo or 5-exo product, generating fused N-heteroaromatic/saturated ring systems. In the experimental materials used by the author, we found 2-Bromopyridin-3-amine(cas: 39856-58-1Application In Synthesis of 2-Bromopyridin-3-amine)
2-Bromopyridin-3-amine(cas: 39856-58-1) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Application In Synthesis of 2-Bromopyridin-3-amine