Development and investigation of a site selective palladium-catalyzed 1,4-difunctionalization of isoprene using pyridine-oxazoline ligands was written by McCammant, Matthew S.;Sigman, Matthew S.. And the article was included in Chemical Science in 2015.Recommanded Product: 4-Chloro-2-(4,5-dihydro-1,3-oxazol-2-yl)pyridine The following contents are mentioned in the article:
Palladium-catalyzed 1,4-difunctionalizations of isoprene that produce skipped polyenes were reported. Complex isomeric product mixtures were possible as a result of the difficult-to-control migratory insertion of isoprene into a Pd-alkenyl bond, but good site selectivity was achieved using easily accessible pyrox ligands. Mechanistic studies suggest that the control of insertion was the result of the unique electronic asymmetry and steric properties of the ligand. This study involved multiple reactions and reactants, such as 4-Chloro-2-(4,5-dihydro-1,3-oxazol-2-yl)pyridine (cas: 1423027-73-9Recommanded Product: 4-Chloro-2-(4,5-dihydro-1,3-oxazol-2-yl)pyridine).
4-Chloro-2-(4,5-dihydro-1,3-oxazol-2-yl)pyridine (cas: 1423027-73-9) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C鈥揌 in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Recommanded Product: 4-Chloro-2-(4,5-dihydro-1,3-oxazol-2-yl)pyridine