In 2022,Meena, Priyanka; Ayushee; Patel, Monika; Verma, Akhilesh K. published an article in Chemical Communications (Cambridge, United Kingdom). The title of the article was 《Transition-metal-free regioselective hydroamination of styrenes with amino-heteroarenes》.Safety of 6-Bromopyridin-3-amine The author mentioned the following in the article:
The base-mediated anti-Markovnikov hydroamination of functionally varied styrenes with amino-substituted pyridines, quinoline, pyrimidine, pyrazine with excellent regioselectivity to afford arylalkyl nitrogen heterocycles I [R1 = H, 4-Me, 6-Me, 4-CF3, etc; R2 = H, 4-Me, 4-Cl, etc.] and II [R3 = Ph, 4-MeC6H4, 1-naphthyl, 4-tBuC6H4; X = N; Y = N] was described. Double hydroamination was observed chemoselectively on the secondary amine, leaving the primary amine intact. The results came from multiple reactions, including the reaction of 6-Bromopyridin-3-amine(cas: 13534-97-9Safety of 6-Bromopyridin-3-amine)
6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Safety of 6-Bromopyridin-3-amine