Mei, Tian-Sheng; Werner, Erik W.; Burckle, Alexander J.; Sigman, Matthew S. published the artcile< Enantioselective Redox-Relay Oxidative Heck Arylations of Acyclic Alkenyl Alcohols using Boronic Acids>, SDS of cas: 1416819-91-4, the main research area is acyclic alkenol arylboronic acid enantioselective regioselective oxidative Heck arylation; aryl aldehyde stereoselective preparation; ketone aryl stereoselective preparation.
A general, highly selective asym. redox-relay oxidative Heck reaction using achiral or racemic acyclic alkenols and boronic acid derivatives is reported. This reaction delivers remotely functionalized arylated carbonyl products from acyclic alkenol substrates, with excellent enantioselectivity under mild conditions, bearing a range of useful functionality. A preliminary mechanistic investigation suggests that the regioselectivity of the initial migratory insertion is highly dependent on the electronic nature of the boronic acid and more subtle electronic effects of the alkenyl alc.
Journal of the American Chemical Society published new progress about Aldehydes Role: SPN (Synthetic Preparation), PREP (Preparation) (aralkyl). 1416819-91-4 belongs to class pyridine-derivatives, and the molecular formula is C13H15F3N2O, SDS of cas: 1416819-91-4.